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Brian A Irving, PhD

Staff Scientist


Geisinger Obesity Institute
100 North Academy Avenue
Danville, PA 17822
Phone: 570-271-6439
Fax: 570-271-6852


MS, University of Virginia, 2001-2004
PhD, University of Virginia, 2001-2006
Postdoctoral Training, Mayo Clinic, 2006-2009


Obesity, Cardiovascular Sciences, Vascular Disease, Regeneration, Women's Health


Exercise Physiology, Body Composition, Metabolism, Muscle Physiology, Stable-Isotopes


I am a PhD trained exercise physiologist, with advanced training in i) endocrinology and metabolism, ii) skeletal muscle physiology, and iii) stable-isotope methodologies. My current research direction is aimed at developing a more thorough understanding of the short- and long-term metabolic and proteomic adaptions to exercise, dietary, pharmacological and surgical interventions in obese patients with cardiometabolic disease. Specifically, I am interest in skeletal muscle, adipose tissue, and hepatic tissue adaptations that provide protection against cardiometabolic disease (e.g., type 2 diabetes, cardiovascular disease, and peripheral vascular disease).

As a member the Geisinger Obesity Institute, I am developing a human metabolic phenotyping core laboratory. Our human metabolic phenotyping core laboratory will initially focus on measures of cardiorespiratory fitness, body composition, physical activity, and energy balance. In addition,  we will also develop protocols to assess changes in substrate (glucose, fat, and protein) metabolism both at rest and during exercise. These services will undoubtedly enhance the ongoing efforts of the Geisinger Obesity Institute and will facilitate collaborations both within and outside of Geisinger.

In addition, I am also setting-up a complementary basic science laboratory in the Weis Center for Research that will focus on skeletal muscle, adipose tissue, and liver tissue physiology. In particular, we will assess the effects of exercise, dietary, pharmacological and surgical interventions on these important metabolic organs in obese patients with cardiometabolic disease. To accomplish our goals we will employ high-resolution respirometry to examine tissue specific changes in mitochondrial bioenergetics, and we will also utilize stable-isotope methodologies to further assess changes in nutrient metabolism as well as changes in protein turnover (i.e., protein synthesis and protein degradation) in response to these divergent interventions.


Irving BA, Robinson MM, Nair KS. (2012, July). Age Effect on Myocellular Remodeling: Response to Exercise and Nutrition in Humans. Ageing Res Rev , 11(3), 374-389.   

Grubina R, Irving BA, Soop M, Srinivasan M, Tatpati L, Chow L, Weymiller A, Carter RE, Nair KS. (2012, June). Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance. Mayo Clinic Proceedings , 87(6), 561-570.   

Di Camillo B, Irving BA, Schimke J, Sanavia T, Toffolo G, Cobelli C, Nair KS. (2012, March). Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells. PLoS One , 7(3),e32391.   

Irving BA, Nair KS, Srinivasan, M. (2011, April). Effects of Insulin Sensitivity, Body Composition, and Fitness on Lipoprotein Particle Sizes and Concentrations Determined by Nuclear Magnetic Resonance. J Cli Endo Met , 96(4), E713-718.   

Irving BA, Short KR, Nair KS, Stump C. (2011, July). Nine Days of Aerobic Interval Training Improves Mitochondrial Function but not Insulin Action in Offspring of Type 2 Diabetics. J Clin Endo Met , 96(7), E1137-1141.   

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